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تحميل الدليل التدريبي

أسئلة شائعة


 

         CURRICULUM VITAE   PDF

Majed Saleh Alokail

 

Nationality:                Saudi Arabia.

e-Mail Address:         msalokail@yahoo.com.

Current Position:        Associate Professor

Present Address:       Department of Biochemistry, College of Science #5,

King Saud University, P.O. Box 2455, Riyadh 11451

Tel. ++9661-467-5943, Fax. ++9661-467-5931

Qualifications:

1-  BSc., Biochemistry, King Saud University in Riyadh, Saudi Arabia.

2-  MSc., Biochemistry, King Saudi University in Riyadh, Saudi  Arabia.

3- High diploma in Insulin Gene Therapy, Gunma University, Maebashi, Japan

4- Ph.D in Molecular Pharmacology at University of Southampton, UK.

 

Research Interest:

1-     Cancer Molecular Biology

2-     Molecular Pharmacology

3-     Apoptosis and Molecular Signaling

4-     Endocrinology

 

Post-Doctoral Fellowships:

1-     Canadian Breast Cancer Society for postdoctoral fellowship in Department of Biochemistry and Molecular Biology at University of Manitoba, Winnipeg, Canada

2-     Sabbatical leave at Cancer Science Center at University of Southampton, Southampton, UK and Endocrine Unit at Harvard Medical School, Boston, MA, USA between June 2005 and September 2006.

3-     AACR – AVON Breast Cancer Foundation Award for a presented paper entitle " Induction of erbB1 and erB2 Receptors by PTHrP in Breast Cancer Cells" in the 96th Annual Meeting of American Cancer Research (AACR) in Los Angeles, CA.USA, 2005.

4-     British Airspace Summer Postdoctoral Fellowship on at Cancer Science Center at University of Southampton, Southampton, UK. June – September, 2005.

5-     Postdoctoral fellowship for summer visit to Southampton University June 16, 2004 until August 18, 2004.

6-     British Airspace Summer Postdoctoral Fellowship on 2002 at Cancer Science Center at University of Southampton, Southampton, UK. June 9, 2002 until September 7th  2002.

7-     British Airspace Summer Postdoctoral Fellowship on at Cancer Science Center at University of Southampton, Southampton, UK. June 11, 2003 until September 11th  2003.

8-     Postdoctoral fellowship for summer visit at Dept., of Pharmacology, University of Texas Medical Branch, Galveston, Texas. USA. From June 16, 2001 until August 31, 2001.

9-     Canadian Breast Cancer Society for post-doctoral fellowship in Department of Biochemistry and Molecular Biology at University of Manitoba, Winnipeg, Canada

10- Japanese Government Scholarship (MONBUSHO) from March, 1991 to September,1992.

 

Membership of Scientific Associations:

1- American Diabetes Association                                                

2- Federation of American Societies for Experimental Biology 

3- American Bone and Mineral Research                                    

4- American Association for Cancer Research                            

5- American Endocrine Society                                                    

 

Book publication.

Title of the chapter: Molecular Signaling of PTHrP in Tumor, MS Alokail.

In Novel aspects of PTHrP physiopathology; Editors: C. Luparello, Nova publishers, Book Chapter (2007).

 

Research Papers:

1- O.S. Al-Attas and M.S. Alokail. Features of insulin receptor interaction in   placenta from normal, overt and poorly controlled gestational diabetic    patients. Molecular & Cellular Biochemistry. (Netherlands) 1991, 126: 135-142.

2- M.S. Alokail and O.S. Al-Attas. Histological changes in Placental   Syncytiotrophoblast of poorly controlled gestational diabetic patients.           Endocrine Journal.(Japan) 1994, 41(4), 355-360.

3- M.S. Alokail. Modefied Iodo-Gen method for peptide hormones iodination.            Journal of Saudi Chememical Society, 2002, 6:15-20.

4- M.S. Alokail. Potential regulation of PTH/PTHrP receptor expression in      choriocarcinoma JAR cell line. Saudi Medical Journal, 2004, 25: 615-         620.

5- M.S. Alokail and S.A. Alarifi. Histological changes in lung of Wistar albino rats        (Rattus norvegicus) after exposure to the Arabian incense (Genus   Boswellia).       Annals of Saudi Medicine, 2004, 24: 217-219.

6- M.S. Alokail. PTHrP Gene Transfection Regulates Colon Cancer Cells       Proliferation. Portugal. Medimond International Proceedings. 2004,       1467-1471.

7- S.A. Alarifi M. Mubarak and M.S. Alokail. Ultrastructural changes of         pneumocytes of rat exposed to Arabian incense (Bakhour). Saudi Medical           Journal. 2004 Nov;25(11):1689-93..

8- S.A. Alarifi, M. Mubarak, M.S. Alokail. Ultrastructure of the Pulmonary       Alveolar  cells of rats exposed to Arabian mix incense (Ma'amoul). Journal of  Biological Sciences. In press. 4:6: 694-697, 2004.

9- M.S. Alokail and M. Alhasan. Thermo Stable Characteristics of Arabian Palm Date (Phoenix Dactylifera L.) Peroxidase. Saudi Journal of Biological  Sciences. 2005: 12; 1; 25-31.

10- Alokail MS. Transient transfection of epidermal growth factor receptor gene into   MCF7 breast ductal carcinoma cell line. Cell Biochemistry and  Function.            2005;23(3):157-161.

11- Alokail MS. Influence of parathyroid hormone-related peptide gene in colon          cancer cell line growth. Saudi Med J. 2005 May;26(5):714-717.

12- Barnes, J.D., Arhel, N.J., Lee, S-S., Sharp, A., Alokail, M.S, Packham, G.,         Hague, A., Paraskeva, C and Williams, A.C. Nuclear BAG-1 expression       inhibits apoptosis in colorectal adenoma derived epithelial cells: Implications in colorectal tumour development. Apoptosis. 2005      Mar;10(2):301-11.

13- Al-Mansouri LJ, and Alokail MS. Molecular basis of breast cancer. Saudi           Med J. 2006 Jan;27(1):9-16.

14- Ahmed MH, Osman MM, and Alokail MS. Statins and breast cancer: a smoking  gun or guilt by association? Expert Opinion Drug Safety. 2006 Sep;5(5):599-601.

15- Alokail MS and Peddie MJ. Characterisation of ligand binding to the         parathyroid hormone /parathyroid hormone-related peptide receptor in        MCF7 breast cancer cells and SaOS-2 osteosarcoma cells. Cell           Biochemistry and  Function. 2007;25: 139-147.

16- Alokail MS. Comparative effects of vitamin D and EB1089 analoge in mRNA       expression of parathyroid hormone-related peptide in prostate and breast   cancer cells. Endocrine Abstracts. 2007: 13; P120.

17- Alokail  MS and Peddie MJ. Quantitative Comparison of PTH1R in Breast 

            Cancer MCF7 and Osteosarcoma SaOS-2 Cell Lines. Submitted to

            Biochemistry and  Function.
           

18- Alenad AM and Alokail MS. Nanoparticles: Promising Tools for Genomic

            Application. Submitted to Arabian Journal of Chemistry.

 

Poster or Oral Presentation in International Conferences:

1- M.S. Alokail and OS. Al-Attas (1990) Characterization of insulin-receptor interaction in Saudi diabetic pregnancy. On Fourth Kuwait International Medical Science Conference: Diabetes Mellitus. March 4-8, Univeristy of Kuwait Faculty of Medicine, Kuwait.

 

2- M.S. Alokail and OS. Al-Attas. (1992) Biochemical, Histological and Histochemical changes in diabetic placenta. On first international union of biochemistry and molecular biology (IUBMB): Biochemistry and diseases. June 1-6, Nagoya Congress Center, Japan.

 

3- M.S. Alokail and MJ. Peddie (1997) Parathyroid hormone-related peptide (PTHrP) as an autocrine growth factor in breast cancer MCF7 cells. in Growth Factor Group symposium, November 26TH, St.Thomas's Hospital in London.

 

4- MS. Alokail and MJ. Peddie. (1998) The role of Epidermal Growth Factor. Estradiol and 1,25 Dihydroxycholecalciferol in Production of PTHrP from breast cancer MCF7 Cells.  Journal of Endocrinology. 156: P113.

 

5- M.S. Alokail and MJ. Peddie 1998).Characterisation of parathyroid hormone / parathyroid hormone-related peptide receptors in the breast cancer MCF7 cells. In 80TH annual meeting of American Endocrine Society meeting. P3-143, June 24-27, 1998 in New Orleans, USA

 

6- M.S. Alokail and M.J. Peddie (1998). Effect of parathyroid hormone (1-34) and parathyroid hormone-related peptide (1-34) on epidermal growth factor receptor expression in breast cancer MCF7 cells. In 80TH annual meeting of American Endocrine Society meeting. P3-323, June 24-27, 1998 in New Orleans, USA

 

7- M.S. Alokail and M.J. Peddie (1998). Characterization of the PTHrP specific receptor in MCF-7 breast cancer cells.  Journal of Endocrinology. 159: P42

 

8- M.S. Alokail and JM. Peddie (1999). Regulation of PTH/PTHrP receptor expression in MCF-7 breast cancer and SaOS-2 osteosarcoma cells by dexamethasone, 1,25 DHCC, EGF, E2, and PTHrP-1-34. Journal of Endocrinology. 160: P183

 

9- M.S. Alokail and MJ. Peddie (1999). Effect of EGF, estradiol, 1,25 dihydroxycholicalciferol, and dexamethasone on PTH/PTHrP receptor affinity in MCF-7 breast cancer and SaOS-2 osteosarcoma cells.  Journal of Endocrinology. 160: P184

 

10- M.S. Alokail and MJ. Peddie (1999). Effect of Trp23-PTHrP-1-36 and Ile5-Trp23-PTHrP-1-36 on displacement of 125I-PTHrP-1-34 on breast cancer MCF7 cells and osteosarcoma SaOS-2 cells. In 81st annual meeting of American Endocrine Society, P-118, June 12-15, 1999, San Diego, CA, USA

 

11- M.S. Alokail and MJ. Peddie (2001). Investigation of PTH and PTHrP interactions to the PTH/PTHrP receptor in the choriocarcinoma JAR cell line. In 83rd annual meeting of American Endocrine Society, P2-635, June 20-23, Denver, Co, USA

 

12- M.S. Alokail (2002). Regulation of  choriocarcinoma JAR cell line  proliferation and  PTH/PTHrP receptor expression with EGF, E2, DEX or 1,25 DHCC. In 84th annual meeting of American Endocrine Society (Genome on Endocrinology), P2-230, June 19-22, San Francisco, CA, USA.

 

13- M.S. Alokail (2003) Influence of parathyroid hormone-related peptide gene on proliferation of human colonic cancer cells. The 94th Annual Meeting of American Cancer Research in Toronto, Ontario, Canada

 

14- MS. Alokail. Application of insulin gene therapy in non-endocrine cell line, COS-7. In 6th Saudi Pharmaceutical international conference. 6-9, October, 2003, Riyadh, Saudi Arabia

 

15- M.S. Alokail. Resistin hormone and type II diabetes mellitus. In 6th Saudi Pharmaceutical international conference. 6-9, October, 2003, Riyadh, Saudi Arabia

 

16- M.S. Alokail. New application for iodo-gen iodination with single or multi tyrosine residues in peptide hormones. In the 2nd International conference on chemistry and its applications. 6-9 of December, 2003, Doha, Qatar.

 

17- MS. Alokail. Parathyroid hormone-related peptide gene transfer and colon cancer cell proliferation. In the 23rd Joint Meeting of the British Endocrine Societies. 22nd-24th March 2004 in Brighton, UK

 

18- M.S. Alokail. Parathyroid hormone-related peptide stimulates signal transduction  pathway of ErbB1 and ErbB2 receptors in breast cancer cells.  The 86th Annual Meeting of The American Endocrine Society, P3-34, 16-19, June, 2004, New Orleans, USA.

 

19- M.S. Alokail (2005) Induction of erbB1 and erB2 Receptors by PTHrP in Breast Cancer Cells. The 96th Annual Meeting of American Cancer Research (AACR) in Los Angeles, CA.USA, P5780, page 383.

 

20- M.S. Alokail. PTHrP Induced the Signalling of Breast Cancer MCF7 Cells Transfected with EGFR and erbB2 Receptor Genes. Meeting of The American Endocrine Society,June, 2006: P1-376.

 

21- O.M. Aboulwafa, KM. Youssef, A.M. Al-Okbeid and M.S. Alokail. Modified Estrogens: Synthesis of alkylamino- and alkylthioacetylamino estrone derivatives as anticancer agents. The 7th International Saudi Pharmaceutical Conference. March, 2007, Riyadh. KSA

 

22- O.M. Aboulwafa, m.s. Al-mutairi, KM. Youssef, H.I. Al-Subbagh, O.A. Al-Deeb, A.J. Fatani and M.S. Alokail. Synthesis of some 2- and 4-peptidylestrone derivatives of potential therapeutic activity. The 7th International Saudi Pharmaceutical Conference. March, 2007, Riyadh. KSA

 

    23- Alokail MS. Comparative effects of vitamin D and EB1089 analoge in mRNA  expression of parathyroid hormone-related peptide in prostate and breast cancer  cells. British endocrine society meeting (BES07). March 5th to March 8th, 2007  Birmingham, UK.

 
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