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George E. Carvell, PhD, PT   University of Pittsburgh
SPINAL CORD: Clarke’s Nucleus & Cuneocerebellar Tract
Ventral Root Exit
Muscle & Joint
Proprioceptor Afferents
Cuneocerebellar Tract
The Dorsal Nucleus of Clarke (C) is a column of Projection Neurons located in the dorsomedial aspect of the intermediate gray from the 8th Cervical to the 3rd Lumbar level of the spinal cord. Clarke’s Nucleus receives input from deep proprioceptors associated with the skeletal muscle (Muscle Spindles and Golgi Tendon Organs) and Synovial Joints (capsular, ligament, and articular fat pads) of the ipsilateral lower extremity and trunk. Clarke's Nucleus Neurons project their axons into the ipsilateral Dorsal Spinocerebellar Tract to synapse on cells in the Cerebellum and cells in Nucleus Z in the brainstem. Nucleus Z contains projection neurons that send their axons into the contralateral Medial Lemniscus which ascend to the Thalamus. Thus, Clarke’s Nucleus provides proprioceptive information to both the Cerebellum and to the Cerebral Cortex (via thalamocortical projections) from the trunk and lower extremity. The upper extremity primary afferent proprioceptive information
ascends in the ipsilateral fasciculus cuneatus (Cuneo-cerebellar Tract) to synapse on neurons in the Lateral Cuneate Nucleus in the medulla. The Lateral Cuneate Nucleus contains projection neurons that send their axons to the Cerebellum and to the contralateral Medial Lemniscus.
Dorsal Spino-cerebellar Tract (DSCT)
Dorsal Nucleus
Of Clarke