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George E. Carvell, PhD, PT   University of Pittsburgh
 
NEUROTRANSMITTERS V: THE ‘GLU’ FOR SYNAPTIC REMODELING (GLU, NMDA, LTP & Calcium)
T.L.Petit, Synaptic Plasticity and the Structural Basis of Learning and Memory. IN: Neural Plasticity: A Lifespan Approach Alan R. Liss, Inc. pp. 201-234, 1988. (Fig. 6, p. 228)
1. Synaptic Activation, Calcium Entry
2. Production of New Synaptic Proteins,
Enlargement of Synapse and Spine Head
3. Activation of Internal Cytoskeleton
Change in Synaptic Curvature, Widening and Shortening of Spine Neck
4. Formation of Perforated Synapse
5. Division of the Synapse and Formation of New Dendritic Spines and Dendritic Length
Dendritic Spine
Axon terminal
Ca2+ provides the trigger to generate the ‘capital’ to build bigger and better synapses