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George E. Carvell, PhD, PT   University of Pittsburgh
 
NEUROTRANSMITTERS I: GABA RECEPTORS, AGONISTS & ANTAGONISTS
LEGEND: Figure 6.6 “Microionto-phoresis. This method enables a researcher to apply very small amounts of drugs or neurotransmitter candidates to the surface of neurons. The responses generated by the drug can be compared to those generated by synaptic stimulation.” BC&P p 136
BC&P fig 6.6 p 136
BC&P fig 6.21 p 153
LEGEND: Figure 6.21 “The binding of drugs to the GABAA receptor. The drugs by them-selves do not open the channel, but they change the effect that GABA has when it binds to the channel at the same time as the drug.” BC&P p 153
Kyriazi Fig 1 p 551
Fig 1A shows responses of a rat somatosensory cortex (barrel) neuron to deflections of whiskers on its face. One whisker (C2) has the best excitatory drive to this C2 barrel neuron. Micro-iontophoretic application of GABA (fig 1B) decreases the responsiveness of the cell (increases inhibition). Microionto-phoretic application of the GABA antagonist BMI (Bicuculline Methiodide) dramatically increases responses to deflections of multiple whiskers. Such high activity is seen in rats with
abnormal brain development (see next page).