Carvell, PhD, PTUniversity
NEUROTRANSMITTERS II: INHIBITORY CONTROL FINE TUNES THE
1 IN: D.J. Simons and P.W. Land, Early Experience of Tactile Stimulation Influences Organization of Somatic
Sensory Cortex. Nature 326: 694-697, 1987.
Simple trimming of whiskers early in life produces changes in response properties of barrel neurons recorded in these animals as adults with regrown vibrissae. Deprived barrel neurons have an increased spontaneous activity, increased responses to whisker deflections, and an expansion of receptive fields (more whiskers excite the neuron).The same trimming in adults has no such effect. This appears to be a cortical phenomenon since response properties of thalamic neurons is unaffected by whisker trimming. These effects appear to be permanent.
Deprived Barrel Neuron Responses
Normal Barrel Neuron Responses
whiskers were trimmed in this animal
Experience is Critical for Normal Development of Rat
cortical barrel is a network of neurons that requires fine
tuning of its inputs to work properly. Sensory Experience
early in life is critical for normal function.