Carvell, PhD, PTUniversity
CEREBELLAR CIRCUITRY: Simple and
Complex Purkinje Cell Spikes
spikes are due to Parallel Fiber Activation of Purkinje Cells. Granule cells are
the source of parallel
fiber axons. Granule cells are tonically activated by mossy fiber input.
Complex spikes are due to
direct activation of Purkinje cells by climbing fibers. Climbing fibers originate in
inferior olivary neurons.
Complex spike discharge is infrequent compared to Simple spikes.
31-7 W.T. Thach, The Cerebellum, Chapter 31 IN: Medical Physiology V.B, Mountcastle, ed. Vol 1 St.
Louis: C. V. Mosby,pp.837-858, 1980.