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George E. Carvell, PhD, PT   University of Pittsburgh
 
PERIPHERAL NERVE CONDUCTION: ABNORMAL SALTATORY CONDUCTION
The top left movie shows the normal sequence of events in saltatory conduction in a myelinated axon (Action Current spreads across Internodes to fire an AP at the adjacent Node). Segmental Demyelination may result in slowing of nerve conduction through the unmyelinated portion of the axon (top right movie). Severe demyelination of long expanses of the fiber results in nerve conduction failure (conduction block) in the unmyelinated portion of the nerve fiber (bottom left movie). These movies have sound; please be patient as they load.
GMOMM  2001
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