Peripheral neuromuscular disorders
may arise due to
lesions anywhere from the ventral
horn to the muscle. Clinicians look for tell-tale patterns of weakness. The neurologist employs the clinical neurological exam,
(NCV & EMG), muscle biopsy, and laboratory blood values to make a diagnosis. There are characteristic
features of lower
motor neuron (LMN) disorders, & neuropathic lesions (peripheral nerve) that differ from those of neuromuscular
or myopathic disease. All have weakness
as a common hallmark with variations
that tend to localize the lesion. Prognosis
& response to treatment varies.
Ben.fig 13-31p 421
central nuclei, random large &
small fibers, degenerating & splitting fibers and increased connective
groups of atrophic
fibers, and increased connective tissue where axons have degenerated.