King Saud University
  Help (new window)
Search


Guidelines_English_Final
تحميل الدليل التدريبي

أسئلة شائعة


 

Pharmaceutics IV
Prerequisites:
PHT 322
Course No: PHT 411
Credits: 3
Description: Biopharmaceutics is the science that considers the interrelationship of the physicochemical properties of the drug, the dosage form in which the drug is given, and the route of administration on the rate and extent of drug absorption.
Material in this course is designed to: familiarize students with the biological factors that influence drug absorption; show how the physiochemical characteristics of the drug influence absorption from the GIT; emphasize the importance of dosage form selection and how it affects the clinical outcome; study the factors affecting bioavailability of drugs including pharmacokinetics variability; study the biopharmaceutics of sustained release and new drug delivery systems.

Textbooks:

- Applied Biopharmaceutics and Pharmacokinetics by Leon Shargel and Andrew B.C. Yu

Pharmaceutics IV   

 

 

A- Oral routes  

 

 

 

 

1.Absorption  

2. Distribution 

 3. Metabolism 

     4.Elimination  

       5. Bioavailability 

 

 

 

 

 

 

B- Non-oral routes  

 

 

 

 

1. Introduction 

2. IV. and IM.  

3. Subcutaneous and other Parental routes 

4. Inhalation routes 

5. Ocular routes 

6. Nasal route 

7. Transdermal routes 

8.  Sublingual and Buccal routes 

9. Rectal and vaginal route

10. Prolonged release medication

11. Novel delivery systems 

12. Targeted drug delivery systems 

  

LECTURES’ OUTLINE (Syllabus) PHT 414 ( Biopharmaceutics )  2+1

  

Week

Lecture number

Topic

1

 

 

1

Introduction to biopharmaceutics

2

Gastrointestinal absorption:

- Biologic consideration

- Membrane physiology

2

3

Mechanisms of drug absorption after oral administration

4

 

 

 

Physiological factors affecting drug absorption from the GIT.

-          Surface area of the gastro-intestinal absorption site.

-          PH of the GIT.

-          Gastric emptying rate.

-          Intestinal motility.

-          Hepatic metabolism.

-          Effect of food.

-          Drug absorption interactions.

3

5

 

 

6

4

 

 

7

Physicochemical factors affecting drug absorption from the GIT.

 - PH partition theory.

   -  Dissociation constant and GIT pH.

    - Lipid solubility.

     - Deviation from the pH partition 
        theory

  - Effect of dissolution rate.

     - Noyes-Whitney equation.

     - Effect of particle size.

      - Solid dispersion and solid solution

      - Crystal form.

      - Solubility in the diffusion layer.

   - Complexation and adsorption.

    -  Chemical stability of drugs in
       the gastrointestinal fluids

 

 

8

5

 

 

9

 

 

10

6

11

12

 

Dosage form factors influencing drug absorption from the GIT.

 - Effects of excipients.

  -Effects of dosage form type.

 

7

13

14

8

15

Bioavailability and Bioequivalance.

16

9

17

 

Biopharmaceutics of non-oral medications.

-          Skin.

-          Buccal and sublingual

-          Rectal administration.

-          Parenteral administration.

-          Inhalational administration.

 

18

 

10

19

 

 

20

 

 

 

 

Biopharmaceutics of sustained release products.

-          Drug absorption and duration of action.

-          Frequency of dosing and therapeutic index.

-          Steady state concentrations and release rate.

-          Kinetics of drug release.

-          Limitations of prolonged-release medications

11

21

 

 

22

 

12

23

24

 

New drug delivery systems.

-          Parenteral and ocular drug delivery systems.

-          Intrauterine devices.

-          Transdermal drug delivery systems (TDDS).

-          Intranasal drug delivery systems

13

25

 

26

 

14

27

28

Exam

 

King   Saud University. All rights reserved, 2007 | Disclaimer | CiteSeerx