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تحميل الدليل التدريبي

أسئلة شائعة



Dr. Abdulaziz A. AL-Yahya

Associate Professor
Pharmacology Department,                                                                                                                                     Director of Research Center,
College of Pharmacy

King Saud University 
P.O. Box 2457, Riyadh 11451
Kingdom of Saudi Arabia
Tel: 00966 1 476-7174
Fax:00966 1 476-7200



| Education | Experience | Affiliations | Research Skills Include 
Specific Research | Representative Publication | References




Ph.D. in Pharmacology and Toxicology (Central Nervous System)
2002 University of Kansas, Lawrence, KS. USA

M.S. in Pharmacology and Toxicology
2000 University of Kansas, Lawrence, KS. USA

B.S., Pharmacy
1994 King Saud University. KSA




  • Work as intern Pharmacist in King Fahad specialist Hospital (1993) Buridah, KSA
  • Teaching assistant in the Pharmacology and Toxicology Department, School of Pharmacy, King Saud University  (1994) Riyadh, KSA
  • Graduate research in pharmacology and toxicology, School of Pharmacy, University of Kansas  (1995-2002)  Lawrence, KS.
  • Teaching pharmacology to undergraduate students in the University of Kansas, School of Pharmacy (1999)
  • Teaching pharmacology to undergraduate students in the School of Pharmacy, and School of Dentistry, King Saud University  (2002- present) Riyadh, KSA
  • Teaching pharmacology and therapeutics to students of Saudi Board for Oral and  Mixillofacial surgery (2003-present) 



  • Member of Saudi Pharmaceutical Society since 1993.
  • Member of American Society of Health-System Pharmacist since 1994.
  • Member of Society for Neuroscience since 1997
  • Presented papers in neuroscience scientific meetings 1998 and 2001.
  • Member of the annual report committee, College of Pharmacy, King Saud University.



  • Preparation of synaptic plasma membranes by ficoll density gradient purification and sucrose density gradient purification.
  • Affinity chromatographic isolation of proteins.
  • Polyacrylamide gel electrophoresis and Western blot analysis
  • Generation of polyclonal antibodies.
  • Immunohistochemical labeling of hippocampal neurons and sections of rat brain.
  • Immunoprecipitation experiments.
  • Cell viability assays: MTT and LDH.
  • Whole-cell patch clamp procedure for measuring agonist-activated currents in neurons


My research focuses on the characterization of NMDA receptor-like complex. NMDA receptors represent a very important class of receptors that can be activated by the neurotransmitter glutamate. These receptors play a major role in long-term potentiation, memory formation, and neuronal degeneration. NMDA receptors consist of NMDAR1, NMDAR2A-2D, and NMDAR3. Our laboratory identified an NMDA receptor-like complex comprised of different proteins from NMDAR1-R3. These are a glutamate-binding protein (GBP), a (±)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP)-binding protein (CPP-BP), a glycine-binding protein GlyBP, and an N-[1-(2-thienyl)cyclohexyl] piperidine (TCP)-binding protein (TCP-BP). Polyclonal antibodies against the native GlyBP subunit of rat brain have been generated and used to study the structure and function of the NMDA receptor-like complex and this was my main part in this project. Immunohistochemical and biochemical studies were carried out using the polyclonal antibodies for GlyBP together with those for two other subunits, GBP and CPPBP. The results from studies of immunohistochemical localization indicated that GlyBP, GBP, and CPPBP distributed in brain regions known to have glutamatergic neurotransmission. Within those regions, the three proteins were expressed in neurons, and in particular in cell bodies and dendrites of neurons. Co-immunoprecipitation experiments demonstrated the association of GlyBP with GBP and CPPBP, but not with either NR1 or NR2. Therefore, NMDA receptor proteins did not appear to interact with those of the receptor-like complex. In the studies of NMDA-induced toxicity and NMDA-induced currents in hippocampal neurons, the anti-GlyBP antibodies protect neurons from NMDA-induced neurotoxicity and partially inhibited NMDA-induced currents. The latter inhibition was specific not only for NMDA-induced currents but also for immune IgG against the GlyBP. Based on the lack of interaction between GlyBP and NMDAR1/R2 the effects of the anti-GlyBP antibodies on cell viability and currents were indicative of a receptor-like function for the complex of proteins that includes GlyBP.



Al-Yahya AA, Al-Majed AA, Al-Bekairi AM,. Al-Shabanah OA and Qureshi S (2006)Studies On The Reproductive, Cytological And Biochemical Toxicity Of Ginkgo Biloba In Swiss Albino Mice. Ethnopharmacology, In Press.


Al-Yahya AA, (2006). Protection effects of carvedilol against stress-induced oxidative damage in rats brain. J. Med. Sci., In Press


Al-Yahya AA, Al-Majed AA, Abd-Allah AR, Gado AM, Al-Shabanah OA (2005). Protective effect of arabic gum treatment against cyclophosphamide-induced urinary bladder toxicity in rats. Submitted to Clinical Medicine and Research.


Al-Majed AA, Sayed-Ahmed MM, Al-Omar FA, Al-Yahya AA, Aleisa AM, Al-Shabanah OA (2006) Carnitine esters prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus. Clinical and Experimental Pharmacology and Physiology, In Press.


Al-Majed AA, Sayed-Ahmed MM, Al-Yahya AA, Aleisa AM, Al-Rejaie SS, Al-Shabanah OA (2006) Propionyl-L-carnitine  prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model. Pharmacological Research 53: 278-286.


Al-Majed AA, Al-Yahya AA, Al-Bekairi AM,. Al-Shabanah OA and Qureshi S (2006) Reproductive, cytological and biochemical toxicity of Yohimbe in male swiss albino mice. Asian Journal of Andrology, In Press.


Al-Majed AA, Al-Yahya AA, Al-Bekairi AM, Al-Shabanah OA, Qureshi S (2005) Genetic and biochemical effects of Ginkgo biloba on somatic and germ cells of mice. Saudi Pharmaceutical Journal 13: 148-157.


Abd-Allah AR, Al-Majed AA, Al-Yahya AA, Fouda SI, Al-Shabanah OA (2005) L-carnitine halts apoptosis and myelosuppression induced by Carboplatin in rat bone marrow cell culture. Archives of Toxicology 79: 406-413 .


El Din AG, Al-Yahya AA, Al-Majed AA , Al-Bekairi AM, Mostafa AM (2005) Antioxidant effect of Arabic Gum Against Paraquat-induced lung oxidative stress in mice. J. Med. Sci. 5: 95-100.


Abd-Allah AR, Gado AM, Al-Majed AA, Al-Yahya AA, Al-Shabanah OA (2005). Protective effect of taurine against cyclophosphamide-induced urinary bladder toxicity in rats. Clinical & Experimental Pharmacology & Physiology 32: 167-172.


Al-Majed AA, Al-Yahya AA, Asiri YA, Al-Gonaiah MA, Mostafa AM (2004) Nimesulide prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus. Research Communications in Molecular Pharmacology and Pathology (In Press).


Al-Yahya AA; R. MacKinnon; R. Pal; K. Kumar; E. Michaelis. Subcellular  localization and function of a glycine-binding protein (GlyBP), a subunit of an  NMDA receptor-like   complex.    Society for Neuroscience. 33.4 (2001).


Al-Yahya AA ;R. MacKinnon; ; R. Pal; K. Kumar; E. Michaelis. Definition of ion currents through NMDA receptors and an NMDA receptor-like complex: Effects of ethanol.  Society for Neuroscience. 507.8  (2000)


 E. Michaelis; R. MacKinnon; Al-Yahya AA; R. Pal; K. Kumar. Ethanol inhibits ion 

currents through NMDA receptors but not through an NMDA receptor-like complex. 23rd Annual research society on alcoholism (RSA) Scientific Meeting. (2000)


K.N. Kumar, J. Hunt, C. Leary, J. Strange, R. Pal, Al-Yahya AA , M. L. Michaelis, and E. K. Michaelis. Antibodies Targeted to the putative glycine-binding domain of a glycine/TCP-binding protein (GLY/TCP-BP). Society for Neuroscience.136.1:341, 1998


Al-Yahya AA , R. Pal, R.Ragan, M. Davey, , K.N. Kumar, and E.K.Michaelis. Co-localization of three subunits of an NMDAR-like complex on the surface of a neuron. Society for Neuroscience. 21: 1836, 1997.




Keshava N. Kumar, Ph.D.
Associate Director
Center for Neurobiology and Immunology Research
The University of Kansas
Lawrence, Kansas 66047
Phone: 785-864-4451
Fax: 785-864-3578


Abdulhakeem A. Al-Majed, Ph.D.
Associate Professor,
Department of Pharmacology- Pharmacy College,
King Saud University- P.O. Box 2457 Riyadh 11451,
Saudi Arabia
Phone: 00966 1 46 77 171
Fax: 00966 1 46 77 200




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Professional Experience

2003 – now     IT Consultant

Majles alShura

2004 – now    Scientific Committee Chairman of Prince Fahd ben sultan University (Tabuk)
2004 – now     IT Supreme Committee member in Majlis Alshura
2005 – now     IT Supreme Committee member in the Ministry of Higher Education
2005 – now     Head of the IT strategic planning team - Ministry of  Higher Education
2004 – now     Head of the Strategic committee of the Internet presence in King Saudi university
2004 – now     Head of the Training and exhibition Committee in the College of Computer and Information sciences
1995  -  now   


 Student Corner

Announcement for PHL 451 students: You may download my acne lecture in PowerPoint format from my website. All you need is just to click here.


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